Journal of Rawalpindi Medical College | 2026
Authors: Hamza H.M.; Sidhu S.M.; Jamal N.K.G.; Atiq-Ur-rehman; Shah G.A.; Riaz M.
DOI: 10.37939/jrmc.v30i1.2695
Journal: Journal of Rawalpindi Medical College
Year: 2026
Publisher: Rawalpindi Medical University
Document Type: Article
Open Access: All Open Access; Gold Open Access
Cited by: 0
Cartilage injuries remain a major challenge owing to the avascular nature of cartilage and its limited regenerative capacity. Recent advances in mRNA-based therapeutics have allowed localised and transient expression of proteins relevant to cartilage repair. This literature review synthesises current knowledge on mRNA delivery platforms, highlights key molecular targets, such as SOX9 and FGF18, demonstrated in preclinical models, and summarises emerging translational insights. Although preclinical studies indicate the potential of mRNA-based approaches to enhance cartilage regeneration, substantial challenges, including delivery efficiency, stability within the joint environment, and regulatory complexity, must be addressed to ensure clinical applicability. © 2026, Rawalpindi Medical University. All rights reserved.
Cytokines; Drug Delivery Systems; Lipid Nanoparticles; Messenger RNA; Osteoarthritis; Regenerative Medicine