Journal of Rawalpindi Medical College | 2026
Authors: Qureshi T.; Ali S.; Yasser A.; Hina M.; Fahad T.; Qureshi A.M.
DOI: 10.37939/jrmc.v30i1.2898
Journal: Journal of Rawalpindi Medical College
Year: 2026
Publisher: Rawalpindi Medical University
Document Type: Article
Open Access: All Open Access; Gold Open Access
Cited by: 0
Objective: To compare the therapeutic effects of coenzyme Q10 and L-carnitine on remyelination of the anterior commissure in a cuprizone-induced rat model of multiple sclerosis. Methods: Forty male Sprague Dawley rats were randomly divided into four groups. Group 1 was given a normal diet, and the remaining three groups were MS models and were administered 0.2% cuprizone for 12 weeks. After four weeks, Group 3 received 150 mg/kg/day CoQ10, Group 4 was administered 100 mg/kg/day L-carnitine, and cuprizone treatment continued until week 12. The rats were then dissected, and their brains were removed. Coronal sections were stained with Luxol Fast Blue to demonstrate remyelination. Results: CoQ10 promoted remyelination more effectively than L-carnitine, as evidenced by significantly reduced areas of demyelination. Conclusion: CoQ10 demonstrates greater effectiveness in promoting remyelination compared to L-Carnitine. © 2026.
Carnitine; Coenzyme Q10; Multiple Sclerosis; Remyelination